The Ohio State University Wexner Medical Center is striving to become a zero-waste campus by 2025 (i.e., 90% diversion of non-hazardous waste away from landfills) through an economically sustainable waste diversion program. To make progress towards this ambitious goal within a three-year deadline, the institution must rapidly ramp up its waste diversion and waste prevention practices. The institution has identified three key barriers it must overcome to achieve its zero-waste goal: inadequate staffing and training resources; lack of real-time waste data; and space limitations.